Second-order type Isomorphisms through Game Semantics The characterization of second-order type isomorphisms is a purely syntactical problem (already solved by Roberto Di Cosmo in 1994) that we popose to study under the enlightenment of game semantics. We define a new game model of system F based on hyperforests (starting from ideas of Hughes and Murawski-Ong) in which we show that isomorphisms coincide with the "equality" on hyperforests associated with types. Finally we recover Di Cosmo's equational characterization of type isomorphisms from this equality. This new approach leads to a more geometrical proof of the result. Moreover, taking advantage of the high flexibility of game models, our proof is general enough to be easily applied to different programming features (like fix point operators and control) and thus leads to new results. In this talk I will present the main ideas of the proof, describe the structure of the model and its extensions, and give some directions towards a game semantics approach of some open problems like Curry-style type isomorphisms.